Interesante articulo publicado por la asociación americana de nutrición y que mostró como mejora la actividad y el rendimiento neuronal en areas del cerebro extremadamente importantes en aquellos niños saludables que tomaron dosis adecuadas de Acido Docoxahexaenoico(Dha), Fracción Activa de el Omega 3, versus los que tomaron dosis bajas o no lo tomaron, demostrando una vez mas la necesidad de aportar este acido graso a nuestros hijos en general. Dr Cubrias
Docosahexaenoic acid supplementation increases prefrontal cortex activation during sustained attention in healthy boys: a placebo-controlled, dose-ranging, functional magnetic resonance imaging study1,2,3,4
Robert K McNamara, Jessica Able, Ronald Jandacek, Therese Rider, Patrick Tso, James C Eliassen, David Alfieri, Wade Weber, Kelly Jarvis, Melissa P DelBello, Stephen M Strakowski and Caleb M Adler
1 From the Department of Psychiatry, Center for Imaging Research, Division of Bipolar Disorders Research, University of Cincinnati College of Medicine, Cincinnati, OH (RKM, JA, JCE, DA, WW, KJ, MPD, SMS, and CMA), and the Department of Pathology, University of Cincinnati, Cincinnati, OH (RJ, TR, and PT).
2 Martek Biosciences Corporation, a primary supporter of this study, had no role in the design, implementation, analysis, or interpretation of the research.
3 Supported in part by National Institutes of Health grants MH074858 (to RKM) and DK59630 (to PT), an investigator-initiated research grant from Martek Biosciences Corporation (to RKM), and the Inflammation Research Foundation (RKM).
4 Address requests for reprints and correspondence to RK McNamara, Department of Psychiatry, University of Cincinnati, College of Medicine, 260 Stetson Street, Cincinnati, OH 45219-0516. E-mail: firstname.lastname@example.org.
Background: Emerging evidence suggests that docosahexaenoic acid (DHA, 22:6n–3), the principal omega-3 (n–3) fatty acid in brain gray matter, positively regulates cortical metabolic function and cognitive development. However, the effects of DHA supplementation on functional cortical activity in human subjects are unknown.
Objective: The objective was to determine the effects of DHA supplementation on functional cortical activity during sustained attention in human subjects.
Design: Healthy boys aged 8–10 y (n = 33) were randomly assigned to receive placebo or 1 of 2 doses of DHA (400 or 1200 mg/d) for 8 wk. Relative changes in cortical activation patterns during sustained attention at baseline and endpoint were determined by functional magnetic resonance imaging.
Results: At 8 wk, erythrocyte membrane DHA composition increased significantly from baseline in subjects who received low-dose (by 47%) or high-dose (by 70%) DHA but not in those who received placebo (–11%). During sustained attention, both DHA dose groups had significantly greater changes from baseline in activation of the dorsolateral prefrontal cortex than did the placebo group, and the low-dose and high-dose DHA groups had greater decreases in the occipital cortex and cerebellar cortex, respectively. Relative to low-dose DHA, high-dose DHA resulted in greater decreases in activation of bilateral cerebellum. The erythrocyte DHA composition was positively correlated with dorsolateral prefrontal cortex activation and was inversely correlated with reaction time, at baseline and endpoint.
Conclusion: Dietary DHA intake and associated elevations in erythrocyte DHA composition are associated with alterations in functional activity in cortical attention networks during sustained attention in healthy boys. This trial was registered at clinicaltrials.gov as NCT00662142.